MK-677 vs Ipamorelin

Side-by-side comparison of peptide medications.

FeatureMK-677Ipamorelin
Categorygrowth-hormonegrowth-hormone
AdministrationOral capsuleSubcutaneous injection
Prescription RequiredYesYes

MK-677

An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.

Common uses: Growth hormone elevation, Improved sleep quality, Increased lean mass, Bone density support

Ipamorelin

A selective growth hormone secretagogue receptor (GHSR) agonist that stimulates pulsatile growth hormone release without significantly raising cortisol, prolactin, or appetite. Considered one of the safest GH-releasing peptides.

Common uses: Growth hormone optimization, Anti-aging, Lean muscle support, Fat loss, Improved sleep