Tirzepatide vs Semaglutide

Side-by-side comparison of peptide medications.

FeatureTirzepatideSemaglutide
Categoryweight-lossweight-loss
AdministrationSubcutaneous injection (weekly)Subcutaneous injection (weekly)
Prescription RequiredYesYes

Tirzepatide

A dual GIP/GLP-1 receptor agonist for weight management and type 2 diabetes. Clinical trials show significant weight reduction, often exceeding semaglutide results.

Common uses: Weight loss, Type 2 diabetes management, Metabolic health

Semaglutide

A GLP-1 receptor agonist originally developed for type 2 diabetes, now widely prescribed for weight management. Reduces appetite and slows gastric emptying.

Common uses: Weight loss, Blood sugar regulation, Appetite suppression