Direct Meds vs Fifty 410
A detailed head-to-head comparison of Direct Meds and Fifty 410 — pricing, peptides, consultation models, and patient reviews.
At a Glance
RatingNo reviews
Starting Price$179/mo
Peptides2
ConsultationAsync Telehealth
Lab TestingNo
Shipping5-7 business days
Pros
- Sublingual drop option — no injections required
- Multiple medication formats (injectable + drops)
- Competitive pricing on sublingual options
- Both semaglutide and tirzepatide available
Cons
- Compounded medications only — not FDA-approved
- No insurance accepted
- Limited clinical support beyond prescribing
- Injectable pricing higher than some competitors
- Relatively new with limited reviews
RatingNo reviews
Starting Price$99/mo
Peptides4
ConsultationAsync Telehealth
Lab TestingNo
Shipping2-6 business days
Pros
- No credit card required until after provider approval
- Multi-month supply ships all at once
- $99/mo equivalent on 3-month semaglutide plan
- Most detailed dose-specific tirzepatide pricing in the peer group
- Outstanding independent review record: 4.8/5 on Trustpilot across 4,381 reviews (the largest review sample in this group)
- No subscriptions, no auto-charges, no membership fees
Cons
- All prescription sales are final
- Binding arbitration clause and class-action waiver (Texas law)
- All medications are compounded
- Compounded GLP-1s face active FDA enforcement pressure; supply and legal landscape can change
- Some states require video/phone consultation before approval (adds friction for fully async-seeking patients)
- Monthly tirzepatide at $299/mo is not as competitively priced as the bundle options suggest
Pros & Cons
Peptide Pricing Comparison
| Peptide | Direct Meds | Fifty 410 |
|---|---|---|
| NAD+ | Not offered | Price unavailable |
| Semaglutide | $179/monthly $297/monthly | $99/monthly $199/monthly $299/monthly |
| Sermorelin | Not offered | Price unavailable |
| Tirzepatide | $224/monthly $399/monthly | Price unavailable |
Frequently Asked Questions
Is Direct Meds or Fifty 410 better?
Direct Meds offers 2 peptides and async telehealth consultations. Fifty 410 offers 4 peptides and async telehealth consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Direct Meds or Fifty 410?
Direct Meds starts at $179/month while Fifty 410 starts at $99/month. However, pricing varies by peptide — see the pricing table above for a full breakdown.