Direct Meds vs Knownwell
A detailed head-to-head comparison of Direct Meds and Knownwell — pricing, peptides, consultation models, and patient reviews.
At a Glance
RatingNo reviews
Starting Price$179/mo
Peptides2
ConsultationAsync Telehealth
Lab TestingNo
Shipping5-7 business days
Pros
- Sublingual drop option — no injections required
- Multiple medication formats (injectable + drops)
- Competitive pricing on sublingual options
- Both semaglutide and tirzepatide available
Cons
- Compounded medications only — not FDA-approved
- No insurance accepted
- Limited clinical support beyond prescribing
- Injectable pricing higher than some competitors
- Relatively new with limited reviews
RatingNo reviews
Starting PriceN/A
Peptides2
ConsultationHybrid
Lab TestingNo
Shipping3-5 business days
Pros
- Board-certified obesity medicine physicians provide a level of clinical specialization not available on most telehealth platforms
- Hybrid model allows in-person examination for complex cases, medication intolerance evaluation, and physical assessment
- Insurance-accepted model reduces out-of-pocket costs compared to cash-pay competitors
- Full GLP-1 formulary including brand-name Wegovy and Zepbound, insulating patients from compounding supply disruptions
- Prior authorization support included
- Appropriate for patients with significant comorbidities (T2D, hypertension, sleep apnea) who need specialist-level management
Cons
- Geographic availability is limited to select Northeast markets; not a national platform as of March 2026
- Insurance-based model means access depends on plan participation and prior authorization approval
- Not the fastest or cheapest path to a GLP-1 prescription for patients who simply want access and have no comorbidities
- In-person visit requirement (when clinically appropriate) is a barrier for patients who cannot travel to a clinic
- Limited public information on cash-pay pricing for patients without covered insurance
Pros & Cons
Peptide Pricing Comparison
| Peptide | Direct Meds | Knownwell |
|---|---|---|
| Semaglutide | $179/monthly $297/monthly | Price unavailable |
| Tirzepatide | $224/monthly $399/monthly | Price unavailable |
Frequently Asked Questions
Is Direct Meds or Knownwell better?
Direct Meds offers 2 peptides and async telehealth consultations. Knownwell offers 2 peptides and hybrid consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Direct Meds or Knownwell?
See the pricing table above for a detailed comparison.