Direct Meds vs Sequence
A detailed head-to-head comparison of Direct Meds and Sequence — pricing, peptides, consultation models, and patient reviews.
At a Glance
RatingNo reviews
Starting Price$179/mo
Peptides2
ConsultationAsync Telehealth
Lab TestingNo
Shipping5-7 business days
Pros
- Sublingual drop option — no injections required
- Multiple medication formats (injectable + drops)
- Competitive pricing on sublingual options
- Both semaglutide and tirzepatide available
Cons
- Compounded medications only — not FDA-approved
- No insurance accepted
- Limited clinical support beyond prescribing
- Injectable pricing higher than some competitors
- Relatively new with limited reviews
RatingNo reviews
Starting Price$99/mo
Peptides2
ConsultationHybrid
Lab TestingNo
Shipping3-5 business days
Pros
- Founded by obesity medicine specialists
- Insurance-first approach can save patients hundreds per month on brand-name GLP-1 medications
- Video consultations with experienced clinicians, not just questionnaire-based async reviews
- Prior authorization and insurance appeals support included in membership
- Personalized titration managed through follow-up video visits
Cons
- Higher total cost for cash-pay patients
- The $99/month membership is charged on top of medication costs (unlike all-inclusive platforms)
- No published independent outcomes data for their patient population
- Insurance navigation success varies
- Less established brand than Hims or Ro
Pros & Cons
Peptide Pricing Comparison
| Peptide | Direct Meds | Sequence |
|---|---|---|
| Semaglutide | $179/monthly $297/monthly | $99/monthly $149/monthly |
| Tirzepatide | $224/monthly $399/monthly | Price unavailable |
Frequently Asked Questions
Is Direct Meds or Sequence better?
Direct Meds offers 2 peptides and async telehealth consultations. Sequence offers 2 peptides and hybrid consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Direct Meds or Sequence?
Direct Meds starts at $179/month while Sequence starts at $99/month. However, pricing varies by peptide — see the pricing table above for a full breakdown.