Direct Meds vs Sesame
A detailed head-to-head comparison of Direct Meds and Sesame — pricing, peptides, consultation models, and patient reviews.
At a Glance
RatingNo reviews
Starting Price$179/mo
Peptides2
ConsultationAsync Telehealth
Lab TestingNo
Shipping5-7 business days
Pros
- Sublingual drop option — no injections required
- Multiple medication formats (injectable + drops)
- Competitive pricing on sublingual options
- Both semaglutide and tirzepatide available
Cons
- Compounded medications only — not FDA-approved
- No insurance accepted
- Limited clinical support beyond prescribing
- Injectable pricing higher than some competitors
- Relatively new with limited reviews
RatingNo reviews
Starting Price$25/mo
Peptides2
ConsultationAsync Telehealth
Lab TestingYes
Shipping3-5 business days
Pros
- No subscription, no membership required, no recurring charges
- Lowest consultation cost in the market ($29-$79 per visit)
- Full control over where you fill your prescription
- Orforglipron and Wegovy HD available alongside other branded options
- Broadest medication options
- No long-term commitment
Cons
- You handle medication sourcing, insurance navigation, and pharmacy selection yourself
- No prior authorization assistance
- No coaching, behavioral support, or structured program
- No lab testing included or coordinated
- Clinician quality varies across the marketplace (independent providers, not Sesame employees)
- No ongoing care coordination between visits
Pros & Cons
Peptide Pricing Comparison
| Peptide | Direct Meds | Sesame |
|---|---|---|
| Semaglutide | $179/monthly $297/monthly | $25/monthly $29/monthly $149/monthly |
| Tirzepatide | $224/monthly $399/monthly | Price unavailable |
Frequently Asked Questions
Is Direct Meds or Sesame better?
Direct Meds offers 2 peptides and async telehealth consultations. Sesame offers 2 peptides and async telehealth consultations. The best choice depends on which peptides you need, your budget, and preferred consultation model.
Which is cheaper, Direct Meds or Sesame?
Direct Meds starts at $179/month while Sesame starts at $25/month. However, pricing varies by peptide — see the pricing table above for a full breakdown.