DihexavsP21
Dihexa vs P21 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
A 21-amino-acid peptide that mimics the action of ciliary neurotrophic factor (CNTF). Studied for neurogenesis, cognitive improvement, and neuroprotection. Shows promise in animal models for enhancing memory consolidation and protecting against neurodegenerative decline.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Dihexa vs P21: At a Glance
Full comparison across all key factors.
| Factor | Dihexa | P21 |
|---|---|---|
| Category | cognitive | cognitive |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide | CNTF analog, Colostrinin fragment |
| Administration | Oral or transdermal | Intranasal spray |
| Prescription | Required | Required |
| Providers | 3 providers | 3 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both Dihexa and P21.
| Provider | Dihexa | P21 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $60/one-time | $55/one-time | Async Telehealth | No |
 | $200/monthly | $180/monthly | Video Telehealth | Yes |
 | $260/monthly | $230/monthly | Video Telehealth | Yes |
Key Differences
Dihexa
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
P21
A 21-amino-acid peptide that mimics the action of ciliary neurotrophic factor (CNTF). Studied for neurogenesis, cognitive improvement, and neuroprotection. Shows promise in animal models for enhancing memory consolidation and protecting against neurodegenerative decline.
Which Is Right for You?
Choose Dihexaif…
- You want a cognitive medication
- You prefer oral or transdermal administration
- 3 providers available on our platform
- Your primary goal is cognitive enhancement
- Your primary goal is memory improvement
Choose P21if…
- You want a cognitive medication
- You prefer intranasal spray administration
- 3 providers available on our platform
- Your primary goal is neurogenesis
- Your primary goal is memory consolidation
Frequently Asked Questions
What is the difference between Dihexa and P21?
Which is cheaper, Dihexa or P21?
Can I switch from Dihexa to P21?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.