FOXO4-DRIvsIGF-1 LR3
FOXO4-DRI vs IGF-1 LR3 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
FOXO4-DRI vs IGF-1 LR3: At a Glance
Full comparison across all key factors.
| Factor | FOXO4-DRI | IGF-1 LR3ALLY PICK |
|---|---|---|
| Category | anti-aging | growth-hormone |
| Also Known As | Senostatin, FOXO4-p53 DRI peptide | Insulin-like Growth Factor-1 Long R3, Long R3 IGF-1 |
| Administration | Subcutaneous injection | Subcutaneous or intramuscular injection |
| Prescription | Required | Required |
| Providers | 2 providers | 3 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both FOXO4-DRI and IGF-1 LR3.
| Provider | FOXO4-DRI | IGF-1 LR3 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/per-cycle | $250/monthly | Video Telehealth | Yes |
 | $550/per-cycle | $320/monthly | Video Telehealth | Yes |
 | Not offered | $55/one-time | Async Telehealth | No |
Key Differences
FOXO4-DRI
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
IGF-1 LR3
More ProvidersA long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
Which Is Right for You?
Choose FOXO4-DRIif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is senescent cell clearance
- Your primary goal is tissue rejuvenation
Choose IGF-1 LR3if…
- You want a growth-hormone medication
- You prefer subcutaneous or intramuscular injection administration
- You want more provider options (3 available)
- Your primary goal is muscle hypertrophy
- Your primary goal is fat loss
Frequently Asked Questions
What is the difference between FOXO4-DRI and IGF-1 LR3?
Which is cheaper, FOXO4-DRI or IGF-1 LR3?
Can I switch from FOXO4-DRI to IGF-1 LR3?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.