IGF-1 LR3vsRetatrutide
IGF-1 LR3 vs Retatrutide — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
IGF-1 LR3 vs Retatrutide: At a Glance
Full comparison across all key factors.
| Factor | IGF-1 LR3 | Retatrutide |
|---|---|---|
| Category | growth-hormone | weight-loss |
| Also Known As | Insulin-like Growth Factor-1 Long R3, Long R3 IGF-1 | LY3437943 |
| Administration | Subcutaneous or intramuscular injection | Subcutaneous injection (weekly) |
| Prescription | Required | Required |
| Providers | 3 providers | 3 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both IGF-1 LR3 and Retatrutide.
| Provider | IGF-1 LR3 | Retatrutide | Consultation | Lab Testing |
|---|---|---|---|---|
 | $250/monthly | $450/monthly | Video Telehealth | Yes |
 | $320/monthly | $550/monthly | Video Telehealth | Yes |
 | $55/one-time | Not offered | Async Telehealth | No |
 | Not offered | $480/monthly | Video Telehealth | Yes |
Key Differences
IGF-1 LR3
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
Retatrutide
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
Which Is Right for You?
Choose IGF-1 LR3if…
- You want a growth-hormone medication
- You prefer subcutaneous or intramuscular injection administration
- 3 providers available on our platform
- Your primary goal is muscle hypertrophy
- Your primary goal is fat loss
Choose Retatrutideif…
- You want a weight-loss medication
- You prefer subcutaneous injection (weekly) administration
- 3 providers available on our platform
- Your primary goal is weight loss
- Your primary goal is metabolic health
Frequently Asked Questions
What is the difference between IGF-1 LR3 and Retatrutide?
Which is cheaper, IGF-1 LR3 or Retatrutide?
Can I switch from IGF-1 LR3 to Retatrutide?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.
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