RetatrutidevsSS-31
Retatrutide vs SS-31 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Retatrutide vs SS-31: At a Glance
Full comparison across all key factors.
| Factor | RetatrutideALLY PICK | SS-31 |
|---|---|---|
| Category | weight-loss | anti-aging |
| Also Known As | LY3437943 | Elamipretide, Bendavia, MTP-131 |
| Administration | Subcutaneous injection (weekly) | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers✓ Better | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both Retatrutide and SS-31.
| Provider | Retatrutide | SS-31 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/monthly | $280/monthly | Video Telehealth | Yes |
 | $550/monthly | $350/monthly | Video Telehealth | Yes |
 | $480/monthly | Not offered | Video Telehealth | Yes |
Key Differences
Retatrutide
More ProvidersA next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
SS-31
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
Which Is Right for You?
Choose Retatrutideif…
- You want a weight-loss medication
- You prefer subcutaneous injection (weekly) administration
- You want more provider options (3 available)
- Your primary goal is weight loss
- Your primary goal is metabolic health
Choose SS-31if…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is mitochondrial function
- Your primary goal is cellular energy
Frequently Asked Questions
What is the difference between Retatrutide and SS-31?
Which is cheaper, Retatrutide or SS-31?
Can I switch from Retatrutide to SS-31?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.
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Read guide →Retatrutide Cost: What Will Eli Lilly's Triple-Agonist Cost When It Launches?
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