DihexavsMelanotan II
Dihexa vs Melanotan II — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Dihexa vs Melanotan II: At a Glance
Full comparison across all key factors.
| Factor | Dihexa | Melanotan II |
|---|---|---|
| Category | cognitive | sexual-health |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide | MT-2, MT-II |
| Administration | Oral or transdermal | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers | 3 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both Dihexa and Melanotan II.
| Provider | Dihexa | Melanotan II | Consultation | Lab Testing |
|---|---|---|---|---|
 | $60/one-time | $30/one-time | Async Telehealth | No |
 | $200/monthly | $120/per-vial | Video Telehealth | Yes |
 | Not offered | $110/per-vial | Video Telehealth | No |
 | $260/monthly | Not offered | Video Telehealth | Yes |
Key Differences
Dihexa
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
Melanotan II
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
Which Is Right for You?
Choose Dihexaif…
- You want a cognitive medication
- You prefer oral or transdermal administration
- 3 providers available on our platform
- Your primary goal is cognitive enhancement
- Your primary goal is memory improvement
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- 3 providers available on our platform
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Frequently Asked Questions
What is the difference between Dihexa and Melanotan II?
Which is cheaper, Dihexa or Melanotan II?
Can I switch from Dihexa to Melanotan II?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.