FOXO4-DRIvsMelanotan II
FOXO4-DRI vs Melanotan II — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
FOXO4-DRI vs Melanotan II: At a Glance
Full comparison across all key factors.
| Factor | FOXO4-DRI | Melanotan IIALLY PICK |
|---|---|---|
| Category | anti-aging | sexual-health |
| Also Known As | Senostatin, FOXO4-p53 DRI peptide | MT-2, MT-II |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 2 providers | 3 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
1 provider offers both FOXO4-DRI and Melanotan II.
| Provider | FOXO4-DRI | Melanotan II | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/per-cycle | $120/per-vial | Video Telehealth | Yes |
 | Not offered | $30/one-time | Async Telehealth | No |
 | Not offered | $110/per-vial | Video Telehealth | No |
 | $550/per-cycle | Not offered | Video Telehealth | Yes |
Key Differences
FOXO4-DRI
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
Melanotan II
More ProvidersA synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
Which Is Right for You?
Choose FOXO4-DRIif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is senescent cell clearance
- Your primary goal is tissue rejuvenation
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- You want more provider options (3 available)
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Frequently Asked Questions
What is the difference between FOXO4-DRI and Melanotan II?
Which is cheaper, FOXO4-DRI or Melanotan II?
Can I switch from FOXO4-DRI to Melanotan II?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.