DihexavsSemax
Dihexa vs Semax — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Dihexa vs Semax: At a Glance
Full comparison across all key factors.
| Factor | Dihexa | SemaxALLY PICK |
|---|---|---|
| Category | cognitive | cognitive |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide | ACTH 4-10 Analog |
| Administration | Oral or transdermal | Intranasal spray |
| Prescription | Required | Required |
| Providers | 3 providers | 4 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both Dihexa and Semax.
| Provider | Dihexa | Semax | Consultation | Lab Testing |
|---|---|---|---|---|
 | $60/one-time | $45/one-time | Async Telehealth | No |
 | $200/monthly | $120/monthly | Video Telehealth | Yes |
 | $260/monthly | $160/monthly | Video Telehealth | Yes |
 | Not offered | $140/monthly | Video Telehealth | Yes |
Key Differences
Dihexa
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
Semax
More ProvidersA synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Which Is Right for You?
Choose Dihexaif…
- You want a cognitive medication
- You prefer oral or transdermal administration
- 3 providers available on our platform
- Your primary goal is cognitive enhancement
- Your primary goal is memory improvement
Choose Semaxif…
- You want a cognitive medication
- You prefer intranasal spray administration
- You want more provider options (4 available)
- Your primary goal is cognitive enhancement
- Your primary goal is neuroprotection
Frequently Asked Questions
What is the difference between Dihexa and Semax?
Which is cheaper, Dihexa or Semax?
Can I switch from Dihexa to Semax?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.