FOXO4-DRIvsSemax
FOXO4-DRI vs Semax — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
FOXO4-DRI vs Semax: At a Glance
Full comparison across all key factors.
| Factor | FOXO4-DRI | SemaxALLY PICK |
|---|---|---|
| Category | anti-aging | cognitive |
| Also Known As | Senostatin, FOXO4-p53 DRI peptide | ACTH 4-10 Analog |
| Administration | Subcutaneous injection | Intranasal spray |
| Prescription | Required | Required |
| Providers | 2 providers | 4 providers✓ Better |
| Common Uses |
|
|
Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both FOXO4-DRI and Semax.
| Provider | FOXO4-DRI | Semax | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/per-cycle | $120/monthly | Video Telehealth | Yes |
 | $550/per-cycle | $160/monthly | Video Telehealth | Yes |
 | Not offered | $45/one-time | Async Telehealth | No |
 | Not offered | $140/monthly | Video Telehealth | Yes |
Key Differences
FOXO4-DRI
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
Semax
More ProvidersA synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Which Is Right for You?
Choose FOXO4-DRIif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is senescent cell clearance
- Your primary goal is tissue rejuvenation
Choose Semaxif…
- You want a cognitive medication
- You prefer intranasal spray administration
- You want more provider options (4 available)
- Your primary goal is cognitive enhancement
- Your primary goal is neuroprotection
Frequently Asked Questions
What is the difference between FOXO4-DRI and Semax?
Which is cheaper, FOXO4-DRI or Semax?
Can I switch from FOXO4-DRI to Semax?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.