DihexavsTB-500
Dihexa vs TB-500 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Dihexa vs TB-500: At a Glance
Full comparison across all key factors.
| Factor | Dihexa | TB-500ALLY PICK |
|---|---|---|
| Category | cognitive | recovery |
| Also Known As | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide | Thymosin Beta-4 Fragment |
| Administration | Oral or transdermal | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both Dihexa and TB-500.
| Provider | Dihexa | TB-500 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $60/one-time | $40/one-time | Async Telehealth | No |
 | $200/monthly | $180/monthly | Video Telehealth | Yes |
 | $260/monthly | $240/monthly | Video Telehealth | Yes |
 | Not offered | $195/monthly | Video Telehealth | Yes |
 | Not offered | $165/monthly | Video Telehealth | No |
 | Not offered | $199/monthly | Video Telehealth | Yes |
Key Differences
Dihexa
A small molecule peptidomimetic derived from angiotensin IV that potently activates the HGF/Met signaling system. Animal studies show cognitive enhancement orders of magnitude more potent than BDNF. Studied for Alzheimer's disease and cognitive decline.
TB-500
More ProvidersA synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Which Is Right for You?
Choose Dihexaif…
- You want a cognitive medication
- You prefer oral or transdermal administration
- 3 providers available on our platform
- Your primary goal is cognitive enhancement
- Your primary goal is memory improvement
Choose TB-500if…
- You want a recovery medication
- You prefer subcutaneous injection administration
- You want more provider options (6 available)
- Your primary goal is muscle repair
- Your primary goal is tendon healing
Frequently Asked Questions
What is the difference between Dihexa and TB-500?
Which is cheaper, Dihexa or TB-500?
Can I switch from Dihexa to TB-500?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.