FOXO4-DRIvsMK-677
FOXO4-DRI vs MK-677 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
FOXO4-DRI vs MK-677: At a Glance
Full comparison across all key factors.
| Factor | FOXO4-DRI | MK-677ALLY PICK |
|---|---|---|
| Category | anti-aging | growth-hormone |
| Also Known As | Senostatin, FOXO4-p53 DRI peptide | Ibutamoren |
| Administration | Subcutaneous injection | Oral capsule |
| Prescription | Required | Required |
| Providers | 2 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both FOXO4-DRI and MK-677.
| Provider | FOXO4-DRI | MK-677 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/per-cycle | $120/monthly | Video Telehealth | Yes |
 | $550/per-cycle | $180/monthly | Video Telehealth | Yes |
 | Not offered | $50/one-time | Async Telehealth | No |
 | Not offered | $150/monthly | Video Telehealth | Yes |
 | Not offered | $149/monthly | Async Telehealth | Yes |
 | Not offered | $149/monthly | Video Telehealth | Yes |
Key Differences
FOXO4-DRI
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
MK-677
More ProvidersAn oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Which Is Right for You?
Choose FOXO4-DRIif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is senescent cell clearance
- Your primary goal is tissue rejuvenation
Choose MK-677if…
- You want a growth-hormone medication
- You prefer oral capsule administration
- You want more provider options (6 available)
- Your primary goal is growth hormone elevation
- Your primary goal is improved sleep quality
Frequently Asked Questions
What is the difference between FOXO4-DRI and MK-677?
Which is cheaper, FOXO4-DRI or MK-677?
Can I switch from FOXO4-DRI to MK-677?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.