FOXO4-DRIvsMOTS-c
FOXO4-DRI vs MOTS-c — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
FOXO4-DRI vs MOTS-c: At a Glance
Full comparison across all key factors.
| Factor | FOXO4-DRI | MOTS-c |
|---|---|---|
| Category | anti-aging | anti-aging |
| Also Known As | Senostatin, FOXO4-p53 DRI peptide | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 2 providers | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both FOXO4-DRI and MOTS-c.
| Provider | FOXO4-DRI | MOTS-c | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/per-cycle | $220/monthly | Video Telehealth | Yes |
 | $550/per-cycle | $280/monthly | Video Telehealth | Yes |
Key Differences
FOXO4-DRI
A D-amino acid retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, triggering apoptosis of these 'zombie cells.' A first-in-class senolytic peptide with potential to clear senescent cell burden.
MOTS-c
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Which Is Right for You?
Choose FOXO4-DRIif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is senescent cell clearance
- Your primary goal is tissue rejuvenation
Choose MOTS-cif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is metabolic health
- Your primary goal is insulin sensitivity
Frequently Asked Questions
What is the difference between FOXO4-DRI and MOTS-c?
Which is cheaper, FOXO4-DRI or MOTS-c?
Can I switch from FOXO4-DRI to MOTS-c?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.