IGF-1 LR3vsMK-677
IGF-1 LR3 vs MK-677 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
IGF-1 LR3 vs MK-677: At a Glance
Full comparison across all key factors.
| Factor | IGF-1 LR3 | MK-677ALLY PICK |
|---|---|---|
| Category | growth-hormone | growth-hormone |
| Also Known As | Insulin-like Growth Factor-1 Long R3, Long R3 IGF-1 | Ibutamoren |
| Administration | Subcutaneous or intramuscular injection | Oral capsule |
| Prescription | Required | Required |
| Providers | 3 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both IGF-1 LR3 and MK-677.
| Provider | IGF-1 LR3 | MK-677 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $55/one-time | $50/one-time | Async Telehealth | No |
 | $250/monthly | $120/monthly | Video Telehealth | Yes |
 | $320/monthly | $180/monthly | Video Telehealth | Yes |
 | Not offered | $150/monthly | Video Telehealth | Yes |
 | Not offered | $149/monthly | Async Telehealth | Yes |
 | Not offered | $149/monthly | Video Telehealth | Yes |
Key Differences
IGF-1 LR3
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
MK-677
More ProvidersAn oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Which Is Right for You?
Choose IGF-1 LR3if…
- You want a growth-hormone medication
- You prefer subcutaneous or intramuscular injection administration
- 3 providers available on our platform
- Your primary goal is muscle hypertrophy
- Your primary goal is fat loss
Choose MK-677if…
- You want a growth-hormone medication
- You prefer oral capsule administration
- You want more provider options (6 available)
- Your primary goal is growth hormone elevation
- Your primary goal is improved sleep quality
Frequently Asked Questions
What is the difference between IGF-1 LR3 and MK-677?
Which is cheaper, IGF-1 LR3 or MK-677?
Can I switch from IGF-1 LR3 to MK-677?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.