IGF-1 LR3vsMOTS-c
IGF-1 LR3 vs MOTS-c — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
IGF-1 LR3 vs MOTS-c: At a Glance
Full comparison across all key factors.
| Factor | IGF-1 LR3ALLY PICK | MOTS-c |
|---|---|---|
| Category | growth-hormone | anti-aging |
| Also Known As | Insulin-like Growth Factor-1 Long R3, Long R3 IGF-1 | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Administration | Subcutaneous or intramuscular injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers✓ Better | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both IGF-1 LR3 and MOTS-c.
| Provider | IGF-1 LR3 | MOTS-c | Consultation | Lab Testing |
|---|---|---|---|---|
 | $250/monthly | $220/monthly | Video Telehealth | Yes |
 | $320/monthly | $280/monthly | Video Telehealth | Yes |
 | $55/one-time | Not offered | Async Telehealth | No |
Key Differences
IGF-1 LR3
More ProvidersA long-acting analog of insulin-like growth factor-1 (IGF-1) with an arginine substitution that reduces binding to IGF-binding proteins, extending its half-life. IGF-1 is the primary downstream mediator of growth hormone's anabolic effects.
MOTS-c
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Which Is Right for You?
Choose IGF-1 LR3if…
- You want a growth-hormone medication
- You prefer subcutaneous or intramuscular injection administration
- You want more provider options (3 available)
- Your primary goal is muscle hypertrophy
- Your primary goal is fat loss
Choose MOTS-cif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is metabolic health
- Your primary goal is insulin sensitivity
Frequently Asked Questions
What is the difference between IGF-1 LR3 and MOTS-c?
Which is cheaper, IGF-1 LR3 or MOTS-c?
Can I switch from IGF-1 LR3 to MOTS-c?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.