PT-141vsSemax
PT-141 vs Semax — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A melanocortin receptor agonist that works through the central nervous system to improve sexual arousal. FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women.
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
PT-141 vs Semax: At a Glance
Full comparison across all key factors.
| Factor | PT-141ALLY PICK | Semax |
|---|---|---|
| Category | sexual-health | cognitive |
| Also Known As | Bremelanotide, Vyleesi | ACTH 4-10 Analog |
| Administration | Subcutaneous injection | Intranasal spray |
| Prescription | Required | Required |
| Providers | 5 providers✓ Better | 4 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
4 providers offer both PT-141 and Semax.
| Provider | PT-141 | Semax | Consultation | Lab Testing |
|---|---|---|---|---|
 | $30/one-time | $45/one-time | Async Telehealth | No |
 | $150/per-vial | $120/monthly | Video Telehealth | Yes |
 | $160/monthly | $140/monthly | Video Telehealth | Yes |
 | $200/monthly | $160/monthly | Video Telehealth | Yes |
 | $140/monthly | Not offered | Video Telehealth | No |
Key Differences
PT-141
More ProvidersA melanocortin receptor agonist that works through the central nervous system to improve sexual arousal. FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women.
Semax
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Which Is Right for You?
Choose PT-141if…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- You want more provider options (5 available)
- Your primary goal is sexual dysfunction
- Your primary goal is low libido
Choose Semaxif…
- You want a cognitive medication
- You prefer intranasal spray administration
- 4 providers available on our platform
- Your primary goal is cognitive enhancement
- Your primary goal is neuroprotection
Frequently Asked Questions
What is the difference between PT-141 and Semax?
Which is cheaper, PT-141 or Semax?
Can I switch from PT-141 to Semax?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.