SermorelinvsSS-31
Sermorelin vs SS-31 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to produce and secrete growth hormone naturally. Often used as a gentler alternative to direct HGH therapy.
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Sermorelin vs SS-31: At a Glance
Full comparison across all key factors.
| Factor | SermorelinALLY PICK | SS-31 |
|---|---|---|
| Category | growth-hormone | anti-aging |
| Also Known As | Geref | Elamipretide, Bendavia, MTP-131 |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 14 providers✓ Better | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both Sermorelin and SS-31.
| Provider | Sermorelin | SS-31 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $175/monthly | $280/monthly | Video Telehealth | Yes |
 | $220/monthly | $350/monthly | Video Telehealth | Yes |
| Price unavailable | Not offered | Hybrid | No | |
| Price unavailable | Not offered | Async Telehealth | No | |
 | $35/one-time | Not offered | Async Telehealth | No |
| Price unavailable | Not offered | Hybrid | No | |
 | $185/monthly | Not offered | Video Telehealth | Yes |
| Price unavailable | Not offered | Async Telehealth | No | |
| Price unavailable | Not offered | Hybrid | No | |
 | $160/monthly | Not offered | Video Telehealth | No |
 | $199/monthly | Not offered | Async Telehealth | Yes |
 | $199/monthly | Not offered | Video Telehealth | Yes |
| Price unavailable | Not offered | Hybrid | No | |
| Price unavailable | Not offered | Hybrid | No |
Key Differences
Sermorelin
More ProvidersA growth hormone-releasing hormone (GHRH) analog that stimulates the pituitary gland to produce and secrete growth hormone naturally. Often used as a gentler alternative to direct HGH therapy.
SS-31
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
Which Is Right for You?
Choose Sermorelinif…
- You want a growth-hormone medication
- You prefer subcutaneous injection administration
- You want more provider options (14 available)
- Your primary goal is growth hormone optimization
- Your primary goal is improved sleep
Choose SS-31if…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is mitochondrial function
- Your primary goal is cellular energy
Frequently Asked Questions
What is the difference between Sermorelin and SS-31?
Which is cheaper, Sermorelin or SS-31?
Can I switch from Sermorelin to SS-31?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.