Melanotan IIvsMOTS-c
Melanotan II vs MOTS-c — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Melanotan II vs MOTS-c: At a Glance
Full comparison across all key factors.
| Factor | Melanotan IIALLY PICK | MOTS-c |
|---|---|---|
| Category | sexual-health | anti-aging |
| Also Known As | MT-2, MT-II | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers✓ Better | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
1 provider offers both Melanotan II and MOTS-c.
| Provider | Melanotan II | MOTS-c | Consultation | Lab Testing |
|---|---|---|---|---|
 | $120/per-vial | $220/monthly | Video Telehealth | Yes |
 | $30/one-time | Not offered | Async Telehealth | No |
 | $110/per-vial | Not offered | Video Telehealth | No |
 | Not offered | $280/monthly | Video Telehealth | Yes |
Key Differences
Melanotan II
More ProvidersA synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
MOTS-c
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Which Is Right for You?
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- You want more provider options (3 available)
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Choose MOTS-cif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is metabolic health
- Your primary goal is insulin sensitivity
Frequently Asked Questions
What is the difference between Melanotan II and MOTS-c?
Which is cheaper, Melanotan II or MOTS-c?
Can I switch from Melanotan II to MOTS-c?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.