Melanotan IIvsP21
Melanotan II vs P21 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
A 21-amino-acid peptide that mimics the action of ciliary neurotrophic factor (CNTF). Studied for neurogenesis, cognitive improvement, and neuroprotection. Shows promise in animal models for enhancing memory consolidation and protecting against neurodegenerative decline.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Melanotan II vs P21: At a Glance
Full comparison across all key factors.
| Factor | Melanotan II | P21 |
|---|---|---|
| Category | sexual-health | cognitive |
| Also Known As | MT-2, MT-II | CNTF analog, Colostrinin fragment |
| Administration | Subcutaneous injection | Intranasal spray |
| Prescription | Required | Required |
| Providers | 3 providers | 3 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both Melanotan II and P21.
| Provider | Melanotan II | P21 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $30/one-time | $55/one-time | Async Telehealth | No |
 | $120/per-vial | $180/monthly | Video Telehealth | Yes |
 | $110/per-vial | Not offered | Video Telehealth | No |
 | Not offered | $230/monthly | Video Telehealth | Yes |
Key Differences
Melanotan II
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
P21
A 21-amino-acid peptide that mimics the action of ciliary neurotrophic factor (CNTF). Studied for neurogenesis, cognitive improvement, and neuroprotection. Shows promise in animal models for enhancing memory consolidation and protecting against neurodegenerative decline.
Which Is Right for You?
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- 3 providers available on our platform
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Choose P21if…
- You want a cognitive medication
- You prefer intranasal spray administration
- 3 providers available on our platform
- Your primary goal is neurogenesis
- Your primary goal is memory consolidation
Frequently Asked Questions
What is the difference between Melanotan II and P21?
Which is cheaper, Melanotan II or P21?
Can I switch from Melanotan II to P21?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.