Melanotan IIvsSemax
Melanotan II vs Semax — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
A synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Melanotan II vs Semax: At a Glance
Full comparison across all key factors.
| Factor | Melanotan II | SemaxALLY PICK |
|---|---|---|
| Category | sexual-health | cognitive |
| Also Known As | MT-2, MT-II | ACTH 4-10 Analog |
| Administration | Subcutaneous injection | Intranasal spray |
| Prescription | Required | Required |
| Providers | 3 providers | 4 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both Melanotan II and Semax.
| Provider | Melanotan II | Semax | Consultation | Lab Testing |
|---|---|---|---|---|
 | $30/one-time | $45/one-time | Async Telehealth | No |
 | $120/per-vial | $120/monthly | Video Telehealth | Yes |
 | Not offered | $140/monthly | Video Telehealth | Yes |
 | $110/per-vial | Not offered | Video Telehealth | No |
 | Not offered | $160/monthly | Video Telehealth | Yes |
Key Differences
Melanotan II
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
Semax
More ProvidersA synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragment 4-10. Developed in Russia for cognitive enhancement and neuroprotection, it modulates BDNF and serotonin levels.
Which Is Right for You?
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- 3 providers available on our platform
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Choose Semaxif…
- You want a cognitive medication
- You prefer intranasal spray administration
- You want more provider options (4 available)
- Your primary goal is cognitive enhancement
- Your primary goal is neuroprotection
Frequently Asked Questions
What is the difference between Melanotan II and Semax?
Which is cheaper, Melanotan II or Semax?
Can I switch from Melanotan II to Semax?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.