MK-677vsMOTS-c
MK-677 vs MOTS-c — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
MK-677 vs MOTS-c: At a Glance
Full comparison across all key factors.
| Factor | MK-677ALLY PICK | MOTS-c |
|---|---|---|
| Category | growth-hormone | anti-aging |
| Also Known As | Ibutamoren | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Administration | Oral capsule | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 6 providers✓ Better | 2 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both MK-677 and MOTS-c.
| Provider | MK-677 | MOTS-c | Consultation | Lab Testing |
|---|---|---|---|---|
 | $120/monthly | $220/monthly | Video Telehealth | Yes |
 | $180/monthly | $280/monthly | Video Telehealth | Yes |
 | $50/one-time | Not offered | Async Telehealth | No |
 | $150/monthly | Not offered | Video Telehealth | Yes |
 | $149/monthly | Not offered | Async Telehealth | Yes |
 | $149/monthly | Not offered | Video Telehealth | Yes |
Key Differences
MK-677
More ProvidersAn oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
MOTS-c
A mitochondria-derived peptide encoded within the mitochondrial genome. MOTS-c regulates metabolic homeostasis, enhances insulin sensitivity, and has shown promise in extending healthspan in animal studies. Levels naturally decline with age.
Which Is Right for You?
Choose MK-677if…
- You want a growth-hormone medication
- You prefer oral capsule administration
- You want more provider options (6 available)
- Your primary goal is growth hormone elevation
- Your primary goal is improved sleep quality
Choose MOTS-cif…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is metabolic health
- Your primary goal is insulin sensitivity
Frequently Asked Questions
What is the difference between MK-677 and MOTS-c?
Which is cheaper, MK-677 or MOTS-c?
Can I switch from MK-677 to MOTS-c?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.