RetatrutidevsTB-500
Retatrutide vs TB-500 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Retatrutide vs TB-500: At a Glance
Full comparison across all key factors.
| Factor | Retatrutide | TB-500ALLY PICK |
|---|---|---|
| Category | weight-loss | recovery |
| Also Known As | LY3437943 | Thymosin Beta-4 Fragment |
| Administration | Subcutaneous injection (weekly) | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both Retatrutide and TB-500.
| Provider | Retatrutide | TB-500 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $450/monthly | $180/monthly | Video Telehealth | Yes |
 | $480/monthly | $195/monthly | Video Telehealth | Yes |
 | $550/monthly | $240/monthly | Video Telehealth | Yes |
 | Not offered | $40/one-time | Async Telehealth | No |
 | Not offered | $165/monthly | Video Telehealth | No |
 | Not offered | $199/monthly | Video Telehealth | Yes |
Key Differences
Retatrutide
A next-generation triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 clinical trials show weight loss exceeding tirzepatide, positioning it as the most potent anti-obesity peptide in development.
TB-500
More ProvidersA synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Which Is Right for You?
Choose Retatrutideif…
- You want a weight-loss medication
- You prefer subcutaneous injection (weekly) administration
- 3 providers available on our platform
- Your primary goal is weight loss
- Your primary goal is metabolic health
Choose TB-500if…
- You want a recovery medication
- You prefer subcutaneous injection administration
- You want more provider options (6 available)
- Your primary goal is muscle repair
- Your primary goal is tendon healing
Frequently Asked Questions
What is the difference between Retatrutide and TB-500?
Which is cheaper, Retatrutide or TB-500?
Can I switch from Retatrutide to TB-500?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.
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Read guide →Read guide →Retatrutide: The Triple-Agonist GLP-1 That Could Change Everything
Complete guide to retatrutide — Eli Lilly's triple-agonist (GLP-1/GIP/glucagon) with 28.7% weight loss in trials. Clinical data, how it compares, and when it might be available.
Read guide →Retatrutide Cost: What Will Eli Lilly's Triple-Agonist Cost When It Launches?
No official pricing exists for retatrutide — it hasn't been FDA-approved. Based on Lilly's existing portfolio, expect a list price of $1,000-1,500/mo with LillyDirect pricing potentially reducing that to $299-449/mo. Here's what we know, what we can project, and how to prepare.
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