SS-31vsTB-500
SS-31 vs TB-500 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
SS-31 vs TB-500: At a Glance
Full comparison across all key factors.
| Factor | SS-31 | TB-500ALLY PICK |
|---|---|---|
| Category | anti-aging | recovery |
| Also Known As | Elamipretide, Bendavia, MTP-131 | Thymosin Beta-4 Fragment |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 2 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
2 providers offer both SS-31 and TB-500.
| Provider | SS-31 | TB-500 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $280/monthly | $180/monthly | Video Telehealth | Yes |
 | $350/monthly | $240/monthly | Video Telehealth | Yes |
 | Not offered | $40/one-time | Async Telehealth | No |
 | Not offered | $195/monthly | Video Telehealth | Yes |
 | Not offered | $165/monthly | Video Telehealth | No |
 | Not offered | $199/monthly | Video Telehealth | Yes |
Key Differences
SS-31
A mitochondria-targeting tetrapeptide that concentrates in the inner mitochondrial membrane, protecting cardiolipin from oxidative damage. Restores mitochondrial function in aged and metabolically stressed cells, with clinical trials in heart failure and Barth syndrome.
TB-500
More ProvidersA synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Which Is Right for You?
Choose SS-31if…
- You want a anti-aging medication
- You prefer subcutaneous injection administration
- 2 providers available on our platform
- Your primary goal is mitochondrial function
- Your primary goal is cellular energy
Choose TB-500if…
- You want a recovery medication
- You prefer subcutaneous injection administration
- You want more provider options (6 available)
- Your primary goal is muscle repair
- Your primary goal is tendon healing
Frequently Asked Questions
What is the difference between SS-31 and TB-500?
Which is cheaper, SS-31 or TB-500?
Can I switch from SS-31 to TB-500?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.