Melanotan IIvsTB-500
Melanotan II vs TB-500 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
Melanotan II vs TB-500: At a Glance
Full comparison across all key factors.
| Factor | Melanotan II | TB-500ALLY PICK |
|---|---|---|
| Category | sexual-health | recovery |
| Also Known As | MT-2, MT-II | Thymosin Beta-4 Fragment |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 3 providers | 6 providers✓ Better |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both Melanotan II and TB-500.
| Provider | Melanotan II | TB-500 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $30/one-time | $40/one-time | Async Telehealth | No |
 | $120/per-vial | $180/monthly | Video Telehealth | Yes |
 | $110/per-vial | $165/monthly | Video Telehealth | No |
 | Not offered | $195/monthly | Video Telehealth | Yes |
 | Not offered | $199/monthly | Video Telehealth | Yes |
 | Not offered | $240/monthly | Video Telehealth | Yes |
Key Differences
Melanotan II
A synthetic melanocortin peptide analog that activates multiple melanocortin receptors. Originally studied for tanning, it also has effects on sexual arousal and appetite regulation.
TB-500
More ProvidersA synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Which Is Right for You?
Choose Melanotan IIif…
- You want a sexual-health medication
- You prefer subcutaneous injection administration
- 3 providers available on our platform
- Your primary goal is sexual dysfunction
- Your primary goal is skin pigmentation
Choose TB-500if…
- You want a recovery medication
- You prefer subcutaneous injection administration
- You want more provider options (6 available)
- Your primary goal is muscle repair
- Your primary goal is tendon healing
Frequently Asked Questions
What is the difference between Melanotan II and TB-500?
Which is cheaper, Melanotan II or TB-500?
Can I switch from Melanotan II to TB-500?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.