MK-677vsTB-500
MK-677 vs TB-500 — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Quick Verdict
Based on clinical evidence and real patient data
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
MK-677 vs TB-500: At a Glance
Full comparison across all key factors.
| Factor | MK-677 | TB-500 |
|---|---|---|
| Category | growth-hormone | recovery |
| Also Known As | Ibutamoren | Thymosin Beta-4 Fragment |
| Administration | Oral capsule | Subcutaneous injection |
| Prescription | Required | Required |
| Providers | 6 providers | 6 providers |
| Common Uses |
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Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
5 providers offer both MK-677 and TB-500.
| Provider | MK-677 | TB-500 | Consultation | Lab Testing |
|---|---|---|---|---|
 | $50/one-time | $40/one-time | Async Telehealth | No |
 | $120/monthly | $180/monthly | Video Telehealth | Yes |
 | $150/monthly | $195/monthly | Video Telehealth | Yes |
 | $149/monthly | $199/monthly | Video Telehealth | Yes |
 | $180/monthly | $240/monthly | Video Telehealth | Yes |
 | Not offered | $165/monthly | Video Telehealth | No |
 | $149/monthly | Not offered | Async Telehealth | Yes |
Key Differences
MK-677
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
TB-500
A synthetic fragment of thymosin beta-4, a naturally occurring peptide involved in tissue repair and regeneration. Studied for its ability to promote healing of muscles, tendons, ligaments, and skin.
Which Is Right for You?
Choose MK-677if…
- You want a growth-hormone medication
- You prefer oral capsule administration
- 6 providers available on our platform
- Your primary goal is growth hormone elevation
- Your primary goal is improved sleep quality
Choose TB-500if…
- You want a recovery medication
- You prefer subcutaneous injection administration
- 6 providers available on our platform
- Your primary goal is muscle repair
- Your primary goal is tendon healing
Frequently Asked Questions
What is the difference between MK-677 and TB-500?
Which is cheaper, MK-677 or TB-500?
Can I switch from MK-677 to TB-500?
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.