MK-677vsTirzepatide
MK-677 vs Tirzepatide — independent comparison of uses, administration, pricing across providers, and key differences. Last reviewed April 21, 2026.
Ally VerdictTirzepatide has broader provider availability
Quick Verdict
Based on clinical evidence and real patient data
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Providers: 6Route: Oral capsule
TirzepatideAlly Pick
A dual GIP/GLP-1 receptor agonist for weight management and type 2 diabetes. Clinical trials show significant weight reduction, often exceeding semaglutide results.
Providers: 107Route: Subcutaneous injection (weekly)
Best choice depends on your insurance, budget, and treatment history.Take the quiz to get a personalized recommendation.
MK-677 vs Tirzepatide: At a Glance
Full comparison across all key factors.
| Factor | MK-677 | TirzepatideALLY PICK |
|---|---|---|
| Category | growth-hormone | weight-loss |
| Also Known As | Ibutamoren | Mounjaro, Zepbound |
| Administration | Oral capsule | Subcutaneous injection (weekly) |
| Prescription | Required | Required |
| Providers | 6 providers | 107 providers✓ Better |
| Common Uses |
|
|
Data sourced from FDA prescribing information and peer-reviewed clinical trials. Prices reflect telehealth platform costs as of April 21, 2026. See our methodology.
Pricing by Provider
3 providers offer both MK-677 and Tirzepatide.
| Provider | MK-677 | Tirzepatide | Consultation | Lab Testing |
|---|---|---|---|---|
 | $150/monthly | $450/monthly | Video Telehealth | Yes |
 | $149/monthly | $399/monthly | Async Telehealth | Yes |
 | $180/monthly | $550/monthly | Video Telehealth | Yes |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
 | $50/one-time | Not offered | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $199/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
 | Not offered | $299/monthly | Video Telehealth | Yes |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | In-Person | No | |
 | $120/monthly | Not offered | Video Telehealth | Yes |
| Not offered | Price unavailable | Async Telehealth | No | |
 | Not offered | $450/monthly | Hybrid | Yes |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Video Telehealth | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Video Telehealth | Yes | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $399/monthly | Video Telehealth | No |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $399/monthly | Async Telehealth | No |
 | Not offered | $176/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
 | Not offered | $375/monthly | Video Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $349/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $399/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $224/monthly | Hybrid | No |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Async Telehealth | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $399/monthly | Video Telehealth | No |
 | $149/monthly | Not offered | Video Telehealth | Yes |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $425/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $399/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Async Telehealth | Yes | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Video Telehealth | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $125/monthly | Async Telehealth | No |
| Not offered | Price unavailable | Hybrid | Yes | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | Async Telehealth | No | |
| Not offered | Price unavailable | In-Person | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
| Not offered | Price unavailable | Hybrid | No | |
 | Not offered | $25/monthly | Async Telehealth | No |
Key Differences
MK-677
An oral growth hormone secretagogue that mimics the action of ghrelin, stimulating growth hormone release from the pituitary gland. Unlike injectable peptides, MK-677 is taken orally and has a long half-life.
Category: growth-hormone
Route: Oral capsule
Uses: Growth hormone elevation, Improved sleep quality
Tirzepatide
More ProvidersA dual GIP/GLP-1 receptor agonist for weight management and type 2 diabetes. Clinical trials show significant weight reduction, often exceeding semaglutide results.
Category: weight-loss
Route: Subcutaneous injection (weekly)
Uses: Weight loss, Type 2 diabetes management
Which Is Right for You?
Choose MK-677if…
- You want a growth-hormone medication
- You prefer oral capsule administration
- 6 providers available on our platform
- Your primary goal is growth hormone elevation
- Your primary goal is improved sleep quality
Choose Tirzepatideif…
- You want a weight-loss medication
- You prefer subcutaneous injection (weekly) administration
- You want more provider options (107 available)
- Your primary goal is weight loss
- Your primary goal is type 2 diabetes management
Frequently Asked Questions
What is the difference between MK-677 and Tirzepatide?
MK-677 is a growth-hormone peptide primarily used for growth hormone elevation and improved sleep quality. Tirzepatide is a weight-loss peptide primarily used for weight loss and type 2 diabetes management. MK-677 is administered via oral capsule, while Tirzepatide is administered via subcutaneous injection (weekly).
Which is cheaper, MK-677 or Tirzepatide?
Pricing varies by provider. MK-677 is available from 6 providers and Tirzepatide from 107 providers. Use the pricing table above to compare costs across all providers.
Can I switch from MK-677 to Tirzepatide?
Switching between medications should always be done under medical supervision. Consult with your healthcare provider before making any changes to your treatment plan. 3 providers on our platform offer both medications.
Medical Disclaimer
This comparison is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication. Individual results may vary. The information presented reflects publicly available data and may not account for your specific health situation.
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Read guide →How Much Does Tirzepatide Cost in 2026? Mounjaro, Zepbound & Compounded
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Read guide →MK-677 (Ibutamoren) Telehealth Guide 2026: Providers, Costs & Safety
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